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Abstract

July-September 2014 | Vol. 7 | Issue 3 | Page No 7-10
Distal Arthrogryposis
Siddram J Patil
Centre for Molecular and Metabolic Diagnostics & Research, Narayana Hrudayalaya Hospitals, Bangalore, India
Address for Correspondence Email: drsjpatil@gmail.com
 
Abstract
Congenital multiple joint contractures involving two or more body areas are collectively termed as arthrogryposis. Based on the extent of joint involvement (proximal and/or distal joints), neurological involvement, and involvement of other parts of the body/other organs the etiology and prognosis of arthrogryposis differs.1 Various etiologies of arthrogryposis include single gene mutations, chromosomal anomalies, and intrauterine environmental factors (e.g. fetal crowding, failed termination of pregnancy).1,2 Distal arthrogryposis (DA) are a subset of arthrogryposis characterized by congenital joint contractures predominantly affecting joints of the hands and feet (distal joints) with or without associated anomalies.3 Here we discuss DA – its types, clinical presentation, inheritance and genes, prognosis and genetic counseling.
 
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