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July - September 2021 | Vol. 14 | Issue 3 | 20-21
Methylation, Monogenic Disorders and More
Varun Venkatraghavan MS
Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Address for Correspondence Email: varunms951@gmail.com
The need for accurate gestational age of a neonate need not be stressed. The available methods have limitations in various settings. In this study, the methylation status was studied using reduced representation bisulfite sequencing (RRBS) in DNA extracted from cord blood and placenta. The investigators identified a set of 332 differentially methylated regions (DMRs) that undergo demethylation in late gestational age and a set of 411 DMRs that undergo de novo methylation in late gestational age. The data of samples used for training (5 less than 33 weeks and 5 more than 33 weeks) was used to evaluate 41 ‘test’ samples of neonates from 25 to 40 weeks. A neonatologist using Ballard criteria, assessed the gestational age of the neonates. This study shows that this novel method (RRBS) of studying methylation levels in DNA of white blood cells in cord blood provides an accurate assessment of gestational age and can be used in clinical settings. It seems the design of the epigenetic clock is working and is useful.
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