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Abstract
October to December 2018 | Vol. 11 | Issue 4 | 10-15 | |||
Genetics of Parkinson Disease | |||
Dhanya Lakshmi N1 , Shubha R Phadke2 | |||
1Nizam’s Institute of Medical Sciences, Hyderabad 2Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow | |||
Address for Correspondence Email: dhanyalakshmi@gmail.com | |||
Abstract Parkinson disease is a common neurodegenerative disorder, characterized by bradykinesia, tremor, rigidity and difficulty in initiating movement. It is caused due to loss of dopaminergic neurons in the substantia nigra in the midbrain. Sporadic forms account for 90% of cases and manifest by 60 years of age. Both environmental and genetic factors have been implicated in sporadic forms. Various genes with autosomal dominant, recessive and X linked inheritance have been identified for monogenic forms of Parkinsonism. This brief review is about the latest advances in the understanding of the genetics of Parkinsonism and some of the novel therapeutic approaches that are being tried. | |||
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