| Contributed by: Dr. Divya Agarwal | ||
| Email: dr.divya2512@gmail.com | ||
| This 29 day-old female baby was referred for evaluation of hand and foot anomalies noted since birth. She was born at term gestation and had a normal birth weight. The feeding and activity were normal and there were no other significant systemic complaints. |
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| Answer to PhotoQuiz 26 |
| Amniotic band sequence (OMIM#217100) |
| Amniotic band sequence (amniotic rupture sequence) is a morphologic defect resulting from disruption i.e. interruption of the normal embryonic developmental process. Amnion rupture leads to formation of amniotic bands, which in turn results in a range of clinical manifestations from minor anomalies (constriction rings around the digits) to lethal anomalies (facial clefts, anencephaly, amputation of digits/arm/leg, joint contractures etc). Various theories have been proposed as the underlying cause including vascular anomalies to germ disc disruption. The reported incidence of amniotic band sequence is 1 in 1,200 to 1 in 15,000 live-births. Prognosis depends on the extent of involvement (digits to internal organs). Most cases are sporadic with no risk of recurrence, although there are few reports of familial occurrence. |
| Correct responses were given by: |
| 1. Deepti Saxena, Lucknow |
| 2. Rekha Goyal, Rajasthan |
| 3. Subapriya K, Chennai |
| 4. Prashanth Verma |
| 5. Beena Suresh, Chennai |