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Abstract

October‐December 2017 | Vol. 10 | Issue 4 | Page No 7-14
Inherited Disorders of DNA Repair
Lekshmi Nair, Surya Prabha B and Prajnya Ranganath
Department of Medical Genetics, Nizam’s Institute of Medical Sciences, Hyderabad
Address for Correspondence Email: prajnyaranganath@gmail.com
 
Abstract
DNA repair disorders are inherited disorders resulting from defective DNA repair mechanisms of the cell, most of which have an autosomal recessive pattern of inheritance. Majority of these disorders are associated with immunodeficiency states and an increased predisposition to malignancies. This article reviews the underlying molecular pathology of these conditions and the clinical approach to the relatively common, well characterized disorders in this group.
 
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