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April-June 2016 | Vol. 9 | Issue 2 | Page No 15-29
An approach to genetic disorders affecting the white matter
Vijayalakshmi SR and Prajnya Ranganath
Department of Medical Genetics, Nizam’s Institute of Medical Sciences, Hyderabad, Telangana, India
Address for Correspondence Email: prajnyaranganath@gmail.com
The white matter lies beneath the gray matter and consists of millions of nerve fibre bundles (axons) that serve as functional circuits linking different regions of the brain. White matter forms the bulk of the deep parts of the brain and the superficial parts of the spinal cord. Aggregates of gray matter are spread within the cerebral white matter. The gray matter is primarily associated with cognition and processing, while the white matter serves to conduct the action potentials and coordinate communication between different brain regions. Genetic disorders affecting the white matter of the brain are heterogeneous with variable and overlapping phenotypes. There is an ongoing process for classification of these disorders
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